Full public datasets are available on our Diabetes Public Datasets page.
RESEARCH HIGHLIGHTS
Primary results from the 2IQP study were published in the New England Journal of Medicine. A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes evaluated the use of the Control-IQ+ system in participants with type 2 diabetes.
Extenson phase results from the INHALE-3 study were recently published in Diabetes Technology and Therapeutics. A 13-Week Single-Arm Evaluation of Inhaled Technosphere Insulin Plus Inuslin Degludec for Adults with Type 1 Diabetes and Inhaled Technosphere Insulin Plus Insulin Degludec for Adults with Type 1 Diabetes: The Inhale-3 Extension Study examine the use of inhaled insulin compared to rapid-acting insulin analogs.
ACTIVE STUDIES
- A Randomized Crossover Trial Evaluating the Effect of Inhaled Technosphere Insulin (Afrezza) versus Rapid Acting Analogue Insulin on Exercise-Induced Hypoglycemia in Adults with Type 1 Diabetes Using Automated Insulin Delivery (INHALE-AIDEx); NCT06880835
- Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer): Extension Study (CLVerEx); NCT06177691
- Inhaled Insulin vs. Rapid-Acting Injections for Post-Meal Glucose Control in Women with Gestational Diabetes (INHALE-GDM); NCT06535789
- T1D Pregnancy & Me - Pregnancy Data Repository to Assess Management of Type 1 Diabetes with Diabetes Technology (PRAM-T1D); NCT06959316
- Twiist-T2D: A Single Arm Trial with an Innovative Automated Inuslin Delivery System for Type 2 Diabetes; NCT06853990
COMPLETED STUDIES
- A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes Continuous Glucose Monitoring Study; NCT02017171
- A Pivotal Study of t:slim X2 with Control-IQ Technology; NCT03844789
- A Pivotal Study of t:slim X2 with Control-IQ Technology - Extension Study
- A Randomized Clinical Trial to Assess the Efficacy of Adjunctive Closed Loop Control Versus Sensor-Augmented Pump Therapy in the Management of Type 1 Diabetes; NCT02985866
- A Randomized Clinical Trial to Assess the Efficacy of Predictive Low Glucose Suspend Versus Sensor-augmented Pump Therapy in the Management of Type 1 Diabetes; NCT03195140
- A Randomized, Placebo-controlled, Double-blinded Cross-over Study of the Pharmacologic Action of a GPR119 Agonist on Glucagon Counter-regulation during Insulin-induced Hypoglycemia in Type 1 Diabetes Mellitus; NCT04432090
- A Randomized Trial Evaluating Control-IQ Technology in Adults with Type 2 Diabetes (2IQP); NCT05785832
- A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring on Glycemic Control in Adults with Type 1 Diabetes Using Injections for Insulin Delivery; NCT02282397
- A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring vs Usual Care in Type 2 Diabetes Patients on Multiple Daily Insulin Injections; NCT02282397
- A Randomized Trial to Assess the Effect of Initiating an Insulin Pump in Adults with Type 1 Diabetes Using Multiple Daily Insulin Injections and Continuous Glucose Monitoring; NCT02282397
- A Study of t:Slim X2 with Control-IQ Technology in Youth with Type 1 Diabetes; NCT03844789
- A Validation Study of Home Blood Collection for HbA1c Measurement
- An Observational Study of Adults with Type 3 Diabetes Using the Community-Derived Open-Source Automated Insulin Delivery Loop System (Loop T2D Observational) Study; NCT05951569
- An Observational Study of Individuals with Type 1 Diabetes Using the Loop System for Automated Insulin Delivery
- AIDING - Automated Insulin Delivery for Inpatients with Dysglycemia Feasibility Study; NCT04714216
- Automated Insulin Delivery among Pregnant Women with Type 1 Diabetes (AiDAPT); NCT04938557
- Automated Insulin Delivery in Elderly with T1D (AIDE T1D); NCT04016662
- Closed Loop from Onset in type 1 Diabetes; NCT02871089
- Closing the Loop in Adults with Type 1 Diabetes under Free Living Conditions with Extension to Evaluate Home Use of Closed-Loop Applying Faster Insulin Aspart Versus Standard Insulin Aspart; NCT04055480
- Closing the Loop in Children and Adolescents with T1D in the Home Setting; NCT01778348
- Control-IQ Technology in Individuals with Type 2 Diabetes; NCT05111301
- Continuous Glucose Monitoring in Pregnant Women with Type 1 Diabetes CGM Data Management Center; NCT01788527
- Continuous Glucose Monitoring in T2D Basal Insulin Users; NCT03566693
- Day-and-Night Home Closed-Loop in Young People with Type 1 Diabetes; <ahref="https://clinicaltrials.gov/ct2/show/NCT02925299">NCT02925299
- Direct to Patient Initiation of CGM in Diabetes
- Evaluation of Modified Adhesives with Dexcom G6 Sensors in Individuals with Known G6 Adhesive Reactions (DEXAS); NCT04840446
- Feasibility Assessment of Prototype Nocturnal Hypoglycemia Reduction System
- Glycemic Variability and Fluctuations in Cognitive Status in Adults with Type 1 Diabetes (GluCog)
- Home Testing of Day and Night Closed Loop with Pump Suspend Feature; NCT02523131
- Hybrid Closed Loop and Verapamil for Beta Cell Preservation in New Onsets with T1D (CLVer); NCT04233034
- In Home Closed Loop Reduction of Nocturnal Hypoglycemia and Daytime Hyperglycemia (IHCL) - datasets available on JDRF Public Website
- INHALE-1 - A 26-week Primary Treatment Phase, with 26-week Extension, Open-label, Randomized Clinical Trial Evaluating the Efficacy and Safety of Afrezza versus Rapid-Acting Insulin Analog Injections, Both in Combination with a Basal Insulin, in Pediatric Subjects with Type 1 or Type 2 Diabetes Mellitus; NCT04974528
- INHALE-3 - Afrezza Combined with Insulin Degludec versus Usual Care in Adults with Type 1 Diabetes; NCT05904743
- Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System; NCT01271023
- JDRF Artifical Pancreas Project
- JDRF Continuous Glucose Monitoring (JDRF CGM RCT) - Public Dataset
- Open, Single Arm, Prospective, Multicenter Study of an Investigational Extended Wear Insulin Infusion Set during Home Use in People with Type 1 Diabetes (CB1); NCT06273124
- OP5-005 Using Omnipod 5 in Adults with Type 2 (SECURE-T2D); NCT05815342
- Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children; NCT01823341
- PID vs PID + Fuzzy Logic Crossover Study in Adolescents and Young Adults with Type 1 Diabetes; NCT03040414
- Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use; NCT02137512
- Prospective Real World Data Collection for the Bigfoot Unity Diabetes Management System: The Bigfoot Unity Real World Study (BURST); NCT05088265
- Pump Suspension with Hyperglycemia Minimization Nocturnal Inpatient Safety and Feasibility Study
- Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing;NCT02438189
- Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents; NCT02714972
- Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension: An Outpatient Pilot Feasibility and Efficacy Study; NCT01823341
- Safety Evaluation of an Advanced Hybrid Closed Loop System Using Lyumjev with the Tandem t:slim X2 with Control-IQ in Adults, Adolescents, and Children with Type 1 Diabetes; NCT05403502
- The Artificial Pancreas in the Very Young Children with T1D – Pilot Study; NCT03101865
- The Artificial Pancreas in Very Young Children with T1D; NCT03784027
- The International Diabetes Closed Loop Trial: A Randomized Crossover Comparison of Adaptive Model Predictive Control Artificial Pancreas Versus Sensor Augmented Pump/Predictive Low Glucose Suspend (PLGS) in the Outpatient Setting in Type 1 Diabetes; NCT04436769
- The Insulin-Only Bionic Pancreas Bridging Study
- The Insulin-Only Bionic Pancreas Pivotal Trial: Testing the iLet in Adults and Children with Type 1 Diabetes (Full protocol available here); NCT04200313
- The Insulin-Only Bionic Pancreas Extension Study (Full protocol available here)
- The Pediatric Artificial Pancreas trial: A Randomized Controlled Comparison of the Control-IQ technology Versus Standard of Care in Young Children in Type 1 Diabetes; NCT04796779
- The Pediatric Artificial Pancreas Autormated Initialization Trial (PEDAP-AI); NCT06017089
- Treat-to-Range Controller: Meal Assessment
- Type 1 Diabetes Exercise Initiative: The Effect of Exercise on Glycemic Control in Type 1 Diabetes Pilot Study
- Type 1 Diabetes Exercise Initiative: The Effect of Exercise on Glycemic Control in Type 1 Diabetes Study (Full protocol available here)
- Type 1 Diabetes Exercise Initiative Pediatric Study: The Effect of Exercise on Glycemic Control in Youth with Type 1 Diabetes; Public Website (Full protocol available here
- Virtual Diabetes Specialty Clinic: A Study Evaluating Remote Initiation of Continuous Glucose Monitoring; NCT04765358
T1D Exchange Clinic Network Studies
- A Randomized Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults with Type 1 Diabetes; NCT02258373
- A Study to Assess Continuous Glucose Sensor Profiles in Healthy Non-Diabetic Subjects
- Assessment of Intranasal Glucagon in Children and Adolescents with Type 1 Diabetes; NCT01997411
- Beta Cell Function and Glucose Counter-Regulation During the Progression of Type 1 Diabetes
- Efficacy and Safety of Intranasal Glucagon for Treatment of Insulin Induced Hypoglycemia in Adults with Diabetes; NCT01994746
- Hybrid Closed Loop Insulin Delivery System Data Collection
- Improving Family Management and Glycemic Control in Youth
- Metformin Therapy for Overweight Adolescents with T1D: A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents with Type 1 Diabetes; NCT01881828
- Metformin Therapy for Overweight Adolescents with T1D: Insulin Clamp Ancillary Study for Assessment of Insulin Resistance; NCT02045290
- Mini-Dose Glucagon for Adults with Type 1 Diabetes: A Study to Assess the Efficacy and Safety of Mini-Dose Glucagon for Treatment of Non-Severe Hypoglycemia in Adults with Type 1 Diabetes; NCT02411578
- Racial Differences in Mean CGM Glucose in Relation to HbA1c
- Residual C-Peptide in Patients with Type 1 Diabetes
- Severe Hypoglycemia in Older Adults with Type 1 Diabetes: A Study to Identify Factors Associated with the Occurrence of Severe Hypoglycemia in Older Adults with T1D
- Strategies to Enhance New CGM Use in Early Childhood: A Randomized Clinical Trial Assessing Continuous Glucose Monitoring Alone and Combined with a Behavioral Intervention in Youth less than 8 Years of Age with Type 1 Diabetes; NCT02912728
- The Use of Mini-Dose Glucagon to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes; NCT02660242
- Wireless Innovation for Seniors with Diabetes Mellitus: A Randomized Clinical Trial Assessing Continuous Glucose Monitoring in Older Adults with Type 1 Diabetes; NCT03240432
Diabetes Research in Children Network (DIRECNET) Studies
- A Pilot Study to Assess the Accuracy of Continuous Glucose Monitors in Normal Children; NCT00069602
- A Pilot Study to Assess the Feasibility of Real-Time Continuous Glucose Monitoring in the Management of Infants and Toddlers with Type 1 Diabetes
- A Pilot Study to Evaluate the GlucoWatch 2 Biographer in the Management of Type 1 Diabetes in Children; NCT00069615
- A Pilot Study to Evaluate the Navigator Continuous Glucose Sensor in the Management of Type 1 Diabetes in Children
- A Pilot Study to Evaluate the Safety of Terbutaline in Children with Type 1 Diabetes; NCT00607503
- A Randomized Trial to Assess the Effectiveness of the GlucoWatch Biographer in the Management of Type 1 Diabetes in Children; NCT00069628
- A Randomized Clinical Trial to Assess the Efficacy and Safety of Real-Time Continuous Glucose Monitoring in the Management of Type 1 Diabetes in Young Children (4 to <10 Year Olds); NCT00760526
- Cognitive and Neuroanatomical Consequences of Type 1 Diabetes in Young Children
- Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes; NCT00891995
- Evaluation of Counter-regulatory Hormone Responses during Hypoglycemia and the Accuracy of Continuous Glucose Monitors in Children with T1DM; NCT00607139
- Relationship Between Loss of Beta Cell Function and Loss of the Alpha Cell Response to Hypoglycemia Early in Type 1 Diabetes
- The Accuracy of Continuous Glucose Monitors in Children with Type 1 Diabetes; NCT00069537
- The Effect of Basal Insulin During Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes; NCT00147342
- The Effect of Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes