JCHR

Facilitating multicenter clinical research of diabetic retinopathy, diabetic macular edema and associated conditions.
Diabetic Retinopathy Clinical Research Network (DRCR.net)

Facilitating multicenter clinical research in strabismus, amblyopia and other eye disorders that affect children.
Pediatric Eye Disease Investigator Group (PEDIG) Website

The Cornea Preservation Time Study (CPTS) is a nationwide study, the first of its kind to study whether endothelial keratoplasty (a corneal transplant surgery) using donor corneas preserved beyond 8 days may be as successful as a surgery using donor corneas preserved less than 8 days.
Cornea Preservation Time Study (CPTS) Website

To evaluate systems for reducing nocturnal hypoglycemia and for reducing hyperglycemia after meals in people with type 1 diabetes in a home setting.

To develop algorithms for automated computer control of blood glucose in diabetics and evaluate the effectiveness of experimental systems that incorporate those algorithms.
JDRF Artificial Pancreas Project Website

To improve the care of children with type 2 diabetes by sharing and advocating best care practices resulting from the collection and analysis of treatment outcome data.
Pediatric Diabetes Consortium (PDC) Website

To improve the comprehensive study of type 1 diabetes (T1D) and create new research opportunities through a T1D data exchange with three components —a clinical registry, biobank, and web-based patient portal —and by conducting important clinical research studies
T1D Exchange Website
Clinical Protocols:

• Residual C-Peptide in Patients with Type 1 Diabetes
• Metformin Therapy for Overweight Adolescents with T1D: Insulin Camp Ancillary Study for Assessment of Insulin Resistance
• Racial Differences in Mean CGM Glucose in Relation to HbA1c
• A Randomized Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults with Type 1 Diabetes
• Mini-Dose Glucagon for Adults with Type 1 Diabetes: A Study to Assess the Efficacy and Safety of Mini-Dose Glucagon for Treatment of Non-Severe Hypoglycemia in Adults with Type 1 Diabetes
• Beta Cell Function and Glucose Counter-Regulation During the Progression of Type 1 Diabetes
• The Use of Mini-Dose Glucagon to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes
• Improving Family Management and Glycemic Control in Youth
• Continuous Glucose Monitoring Intervention in Teens and Young Adults (CITY) – a randomized trial of CGM use in teens and young adults. CITY Recruitment Flyer
• Strategies to Enhance New CGM Use in Early Childhood (SENCE) – an RCT assessing continuous glucose monitoring alone and combined with a behavioral intervention in youth less than 8 years of age with type 1 diabetes
• Wireless Innovation for Seniors with Diabetes Mellitus (WISDM) – an RCT assessing continuous glucose monitoring in older adults with type 1 diabetes

To investigate strategies designed to reduce the incidence of hypoglycemia and hyperglycemia in children and young adults.

To determine long-term course of patients with multiple sclerosis who were treated with Avonex at the onset of their first demyelinating event.

To determine the risk of and associated risk factors for multiple sclerosis following optic neuritis and the visual course following optic neuritis.

To evaluate the effectiveness of real-time continuous glucose monitors in the management of type 1 diabetes in children and adults.

To investigate strategies designed to reduce the incidence of hypoglycemia and hyperglycemia in children and young adults.

• Severe Hypoglycemia in Older Adults with Type 1 Diabetes: A Study to Identify Factors Associated with the Occurrence of Severe Hypoglycemia in Older Adults with T1D
• Metformin Therapy for Overweight Adolescents with T1D: A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents with Type 1 Diabetes
• Efficacy and Safety of Intranasal Glucagon for Treatment of Insulin Induced Hypoglycemia in Adults with Diabetes
• Assessment of Intranasal Glucagon in Children and Adolescents with Type 1 Diabetes