Full public datasets are available on our Diabetes Public Datasets page.

RESEARCH HIGHLIGHTS

Primary results from the 2IQP study were published in the New England Journal of Medicine. A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes evaluated the use of the Control-IQ+ system in participants with type 2 diabetes.

Extenson phase results from the INHALE-3 study were recently published in Diabetes Technology and Therapeutics. A 13-Week Single-Arm Evaluation of Inhaled Technosphere Insulin Plus Inuslin Degludec for Adults with Type 1 Diabetes and Inhaled Technosphere Insulin Plus Insulin Degludec for Adults with Type 1 Diabetes: The Inhale-3 Extension Study examine the use of inhaled insulin compared to rapid-acting insulin analogs.

ACTIVE STUDIES

  • A Randomized Crossover Trial Evaluating the Effect of Inhaled Technosphere Insulin (Afrezza) versus Rapid Acting Analogue Insulin on Exercise-Induced Hypoglycemia in Adults with Type 1 Diabetes Using Automated Insulin Delivery (INHALE-AIDEx); NCT06880835
  • Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer): Extension Study (CLVerEx); NCT06177691
  • Inhaled Insulin vs. Rapid-Acting Injections for Post-Meal Glucose Control in Women with Gestational Diabetes (INHALE-GDM); NCT06535789
  • T1D Pregnancy & Me - Pregnancy Data Repository to Assess Management of Type 1 Diabetes with Diabetes Technology (PRAM-T1D); NCT06959316
  • Twiist-T2D: A Single Arm Trial with an Innovative Automated Inuslin Delivery System for Type 2 Diabetes; NCT06853990

COMPLETED STUDIES

  • A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes Continuous Glucose Monitoring Study; NCT02017171
  • A Pivotal Study of t:slim X2 with Control-IQ Technology; NCT03844789
    • A Pivotal Study of t:slim X2 with Control-IQ Technology - Extension Study
  • A Randomized Clinical Trial to Assess the Efficacy of Adjunctive Closed Loop Control Versus Sensor-Augmented Pump Therapy in the Management of Type 1 Diabetes; NCT02985866
  • A Randomized Clinical Trial to Assess the Efficacy of Predictive Low Glucose Suspend Versus Sensor-augmented Pump Therapy in the Management of Type 1 Diabetes; NCT03195140
  • A Randomized, Placebo-controlled, Double-blinded Cross-over Study of the Pharmacologic Action of a GPR119 Agonist on Glucagon Counter-regulation during Insulin-induced Hypoglycemia in Type 1 Diabetes Mellitus; NCT04432090
  • A Randomized Trial Evaluating Control-IQ Technology in Adults with Type 2 Diabetes (2IQP); NCT05785832
  • A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring on Glycemic Control in Adults with Type 1 Diabetes Using Injections for Insulin Delivery; NCT02282397
  • A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring vs Usual Care in Type 2 Diabetes Patients on Multiple Daily Insulin Injections; NCT02282397
  • A Randomized Trial to Assess the Effect of Initiating an Insulin Pump in Adults with Type 1 Diabetes Using Multiple Daily Insulin Injections and Continuous Glucose Monitoring; NCT02282397
  • A Study of t:Slim X2 with Control-IQ Technology in Youth with Type 1 Diabetes; NCT03844789
  • A Validation Study of Home Blood Collection for HbA1c Measurement
  • An Observational Study of Adults with Type 3 Diabetes Using the Community-Derived Open-Source Automated Insulin Delivery Loop System (Loop T2D Observational) Study; NCT05951569
  • An Observational Study of Individuals with Type 1 Diabetes Using the Loop System for Automated Insulin Delivery
  • AIDING - Automated Insulin Delivery for Inpatients with Dysglycemia Feasibility Study; NCT04714216
  • Automated Insulin Delivery among Pregnant Women with Type 1 Diabetes (AiDAPT); NCT04938557
  • Automated Insulin Delivery in Elderly with T1D (AIDE T1D); NCT04016662
  • Closed Loop from Onset in type 1 Diabetes; NCT02871089
  • Closing the Loop in Adults with Type 1 Diabetes under Free Living Conditions with Extension to Evaluate Home Use of Closed-Loop Applying Faster Insulin Aspart Versus Standard Insulin Aspart; NCT04055480
  • Closing the Loop in Children and Adolescents with T1D in the Home Setting; NCT01778348
  • Control-IQ Technology in Individuals with Type 2 Diabetes; NCT05111301
  • Continuous Glucose Monitoring in Pregnant Women with Type 1 Diabetes CGM Data Management Center; NCT01788527
  • Continuous Glucose Monitoring in T2D Basal Insulin Users; NCT03566693
  • Day-and-Night Home Closed-Loop in Young People with Type 1 Diabetes; <ahref="https://clinicaltrials.gov/ct2/show/NCT02925299">NCT02925299
  • Direct to Patient Initiation of CGM in Diabetes
  • Evaluation of Modified Adhesives with Dexcom G6 Sensors in Individuals with Known G6 Adhesive Reactions (DEXAS); NCT04840446
  • Feasibility Assessment of Prototype Nocturnal Hypoglycemia Reduction System
  • Glycemic Variability and Fluctuations in Cognitive Status in Adults with Type 1 Diabetes (GluCog)
  • Home Testing of Day and Night Closed Loop with Pump Suspend Feature; NCT02523131
  • Hybrid Closed Loop and Verapamil for Beta Cell Preservation in New Onsets with T1D (CLVer); NCT04233034
  • In Home Closed Loop Reduction of Nocturnal Hypoglycemia and Daytime Hyperglycemia (IHCL) - datasets available on JDRF Public Website
  • INHALE-1 - A 26-week Primary Treatment Phase, with 26-week Extension, Open-label, Randomized Clinical Trial Evaluating the Efficacy and Safety of Afrezza versus Rapid-Acting Insulin Analog Injections, Both in Combination with a Basal Insulin, in Pediatric Subjects with Type 1 or Type 2 Diabetes Mellitus; NCT04974528
  • INHALE-3 - Afrezza Combined with Insulin Degludec versus Usual Care in Adults with Type 1 Diabetes; NCT05904743
  • Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System; NCT01271023
  • JDRF Artifical Pancreas Project
  • JDRF Continuous Glucose Monitoring (JDRF CGM RCT) - Public Dataset
  • Open, Single Arm, Prospective, Multicenter Study of an Investigational Extended Wear Insulin Infusion Set during Home Use in People with Type 1 Diabetes (CB1); NCT06273124
  • OP5-005 Using Omnipod 5 in Adults with Type 2 (SECURE-T2D); NCT05815342
  • Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children; NCT01823341
  • PID vs PID + Fuzzy Logic Crossover Study in Adolescents and Young Adults with Type 1 Diabetes; NCT03040414
  • Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use; NCT02137512
  • Prospective Real World Data Collection for the Bigfoot Unity Diabetes Management System: The Bigfoot Unity Real World Study (BURST); NCT05088265
  • Pump Suspension with Hyperglycemia Minimization Nocturnal Inpatient Safety and Feasibility Study
  • Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing;NCT02438189
  • Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents; NCT02714972
  • Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension: An Outpatient Pilot Feasibility and Efficacy Study; NCT01823341
  • Safety Evaluation of an Advanced Hybrid Closed Loop System Using Lyumjev with the Tandem t:slim X2 with Control-IQ in Adults, Adolescents, and Children with Type 1 Diabetes; NCT05403502
  • The Artificial Pancreas in the Very Young Children with T1D – Pilot Study; NCT03101865
  • The Artificial Pancreas in Very Young Children with T1D; NCT03784027
  • The International Diabetes Closed Loop Trial: A Randomized Crossover Comparison of Adaptive Model Predictive Control Artificial Pancreas Versus Sensor Augmented Pump/Predictive Low Glucose Suspend (PLGS) in the Outpatient Setting in Type 1 Diabetes; NCT04436769
  • The Insulin-Only Bionic Pancreas Bridging Study
  • The Insulin-Only Bionic Pancreas Pivotal Trial: Testing the iLet in Adults and Children with Type 1 Diabetes (Full protocol available here); NCT04200313
    • The Insulin-Only Bionic Pancreas Extension Study (Full protocol available here)
  • The Pediatric Artificial Pancreas trial: A Randomized Controlled Comparison of the Control-IQ technology Versus Standard of Care in Young Children in Type 1 Diabetes; NCT04796779
  • The Pediatric Artificial Pancreas Autormated Initialization Trial (PEDAP-AI); NCT06017089
  • Treat-to-Range Controller: Meal Assessment
  • Type 1 Diabetes Exercise Initiative: The Effect of Exercise on Glycemic Control in Type 1 Diabetes Pilot Study
  • Type 1 Diabetes Exercise Initiative: The Effect of Exercise on Glycemic Control in Type 1 Diabetes Study (Full protocol available here)
  • Type 1 Diabetes Exercise Initiative Pediatric Study: The Effect of Exercise on Glycemic Control in Youth with Type 1 Diabetes; Public Website (Full protocol available here
  • Virtual Diabetes Specialty Clinic: A Study Evaluating Remote Initiation of Continuous Glucose Monitoring; NCT04765358

T1D Exchange Clinic Network Studies

  • A Randomized Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults with Type 1 Diabetes; NCT02258373
  • A Study to Assess Continuous Glucose Sensor Profiles in Healthy Non-Diabetic Subjects
  • Assessment of Intranasal Glucagon in Children and Adolescents with Type 1 Diabetes; NCT01997411
  • Beta Cell Function and Glucose Counter-Regulation During the Progression of Type 1 Diabetes
  • Efficacy and Safety of Intranasal Glucagon for Treatment of Insulin Induced Hypoglycemia in Adults with Diabetes; NCT01994746
  • Hybrid Closed Loop Insulin Delivery System Data Collection
  • Improving Family Management and Glycemic Control in Youth
  • Metformin Therapy for Overweight Adolescents with T1D: A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents with Type 1 Diabetes; NCT01881828
  • Metformin Therapy for Overweight Adolescents with T1D: Insulin Clamp Ancillary Study for Assessment of Insulin Resistance; NCT02045290
  • Mini-Dose Glucagon for Adults with Type 1 Diabetes: A Study to Assess the Efficacy and Safety of Mini-Dose Glucagon for Treatment of Non-Severe Hypoglycemia in Adults with Type 1 Diabetes; NCT02411578
  • Racial Differences in Mean CGM Glucose in Relation to HbA1c
  • Residual C-Peptide in Patients with Type 1 Diabetes
  • Severe Hypoglycemia in Older Adults with Type 1 Diabetes: A Study to Identify Factors Associated with the Occurrence of Severe Hypoglycemia in Older Adults with T1D
  • Strategies to Enhance New CGM Use in Early Childhood: A Randomized Clinical Trial Assessing Continuous Glucose Monitoring Alone and Combined with a Behavioral Intervention in Youth less than 8 Years of Age with Type 1 Diabetes; NCT02912728
  • The Use of Mini-Dose Glucagon to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes; NCT02660242
  • Wireless Innovation for Seniors with Diabetes Mellitus: A Randomized Clinical Trial Assessing Continuous Glucose Monitoring in Older Adults with Type 1 Diabetes; NCT03240432

Diabetes Research in Children Network (DIRECNET) Studies

  • A Pilot Study to Assess the Accuracy of Continuous Glucose Monitors in Normal Children; NCT00069602
  • A Pilot Study to Assess the Feasibility of Real-Time Continuous Glucose Monitoring in the Management of Infants and Toddlers with Type 1 Diabetes
  • A Pilot Study to Evaluate the GlucoWatch 2 Biographer in the Management of Type 1 Diabetes in Children; NCT00069615
  • A Pilot Study to Evaluate the Navigator Continuous Glucose Sensor in the Management of Type 1 Diabetes in Children
  • A Pilot Study to Evaluate the Safety of Terbutaline in Children with Type 1 Diabetes; NCT00607503
  • A Randomized Trial to Assess the Effectiveness of the GlucoWatch Biographer in the Management of Type 1 Diabetes in Children; NCT00069628
  • A Randomized Clinical Trial to Assess the Efficacy and Safety of Real-Time Continuous Glucose Monitoring in the Management of Type 1 Diabetes in Young Children (4 to <10 Year Olds); NCT00760526
  • Cognitive and Neuroanatomical Consequences of Type 1 Diabetes in Young Children
  • Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes; NCT00891995
  • Evaluation of Counter-regulatory Hormone Responses during Hypoglycemia and the Accuracy of Continuous Glucose Monitors in Children with T1DM; NCT00607139
  • Relationship Between Loss of Beta Cell Function and Loss of the Alpha Cell Response to Hypoglycemia Early in Type 1 Diabetes
  • The Accuracy of Continuous Glucose Monitors in Children with Type 1 Diabetes; NCT00069537
  • The Effect of Basal Insulin During Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes; NCT00147342
  • The Effect of Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes