Facilitating multicenter clinical research of diabetic retinopathy, diabetic macular edema and associated conditions.
DRCR.NET Public Website

Facilitating multicenter clinical research in strabismus, amblyopia and other eye disorders that affect children
PEDIG Public Website

Consortium Accelerating the development of treatments for rare inherited retinal disorders
FFB Public Website

• Rate of Progression in USH2A Related Retinal Degeneration Observational Study

Safety and Feasibility of Cultivated Autologous Limbal Epithelial Cell Transplantation in the Treatment of Limbal Stem Cell Deficiency

To develop algorithms for automated computer control of blood glucose in diabetics and evaluate the effectiveness of experimental systems that incorporate those algorithms.
JDRF Artificial Pancreas Project Website

To improve the care of children with type 2 diabetes by sharing and advocating best care practices resulting from the collection and analysis of treatment outcome data.
Pediatric Diabetes Consortium (PDC) Website

To improve the comprehensive study of type 1 diabetes (T1D) and create new research opportunities through a T1D data exchange with three components —a clinical registry, biobank, and web-based patient portal —and by conducting important clinical research studies
T1D Exchange Study Information
Clinical Protocols:

• Continuous Glucose Monitoring Intervention in Teens and Young Adults (CITY) – a randomized trial of CGM use in teens and young adults.
• Strategies to Enhance New CGM Use in Early Childhood (SENCE) – an RCT assessing continuous glucose monitoring alone and combined with a behavioral intervention in youth less than 8 years of age with type 1 diabetes
• Wireless Innovation for Seniors with Diabetes Mellitus (WISDM) – an RCT assessing continuous glucose monitoring in older adults with type 1 diabetes

• A Pivotal Study of t:slim X2 with Control-IQ Technology (iDCL protocol DCLP3)
• A Study of t:Slim X2 with Control-IQ Technology in Youth with Type 1 Diabetes (iDCL protocol DCLP5)
• An Observational Study of Individuals with Type 1 Diabetes Using the Loop System for Automated Insulin Delivery
• Continuous Glucose Monitoring in T2D Basal Insulin Users (MOBILE)
• Day-and-Night Home Closed-Loop in Young People with Type 1 Diabetes (DAN05)
• PID vs PID + Fuzzy Logic Crossover Study in Adolescents and Young Adults with Type 1 Diabetes (FLAIR)
• Hybrid Closed Loop Insulin Delivery System Data Collection (HYCLO)
• A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes (PERL) Continuous Glucose Monitoring Study
• Closed Loop from Onset in type 1 Diabetes (CLOuD)
• The Artificial Pancreas in Very Young Children with T1D (KidsAP02)
• Closing the Loop in Adults with Type 1 Diabetes under Free Living Conditions with Extension to Evaluate Home Use of Closed-Loop Applying Faster Insulin Aspart Versus Standard Insulin Aspart
• Automated insulin Delivery among Pregnant Women with Type 1 Diabetes (AiDAPT)
• Direct to Patient Initiation of CGM in Diabetes
• Type 1 Diabetes Exercise Initiative: The Effect of Exercise on Glycemic Control in Type 1 Diabetes Pilot Study

To investigate strategies designed to reduce the incidence of hypoglycemia and hyperglycemia in children and young adults.
CDS Public Website

The Cornea Preservation Time Study (CPTS) is a nationwide study, the first of its kind to study whether endothelial keratoplasty (a corneal transplant surgery) using donor corneas preserved beyond 8 days may be as successful as a surgery using donor corneas preserved less than 8 days.
CPTS Public Website

To determine long-term course of patients with multiple sclerosis who were treated with Avonex at the onset of their first demyelinating event.

To determine the risk of and associated risk factors for multiple sclerosis following optic neuritis and the visual course following optic neuritis.

To evaluate the effectiveness of real-time continuous glucose monitors in the management of type 1 diabetes in children and adults.

To investigate strategies designed to reduce the incidence of hypoglycemia and hyperglycemia in children and young adults.

• Severe Hypoglycemia in Older Adults with Type 1 Diabetes: A Study to Identify Factors Associated with the Occurrence of Severe Hypoglycemia in Older Adults with T1D
• Metformin Therapy for Overweight Adolescents with T1D: A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents with Type 1 Diabetes
• Efficacy and Safety of Intranasal Glucagon for Treatment of Insulin Induced Hypoglycemia in Adults with Diabetes
• Assessment of Intranasal Glucagon in Children and Adolescents with Type 1 Diabetes
• Residual C-Peptide in Patients with Type 1 Diabetes
• Metformin Therapy for Overweight Adolescents with T1D: Insulin Camp Ancillary Study for Assessment of Insulin Resistance
• Racial Differences in Mean CGM Glucose in Relation to HbA1c
• A Randomized Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults with Type 1 Diabetes
• Mini-Dose Glucagon for Adults with Type 1 Diabetes: A Study to Assess the Efficacy and Safety of Mini-Dose Glucagon for Treatment of Non-Severe Hypoglycemia in Adults with Type 1 Diabetes
• Beta Cell Function and Glucose Counter-Regulation During the Progression of Type 1 Diabetes
• The Use of Mini-Dose Glucagon to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes
• Improving Family Management and Glycemic Control in Youth
• A Study to Assess Continuous Glucose Sensor Profiles in Healthy Non-Diabetic Subjects

To evaluate systems for reducing nocturnal hypoglycemia and for reducing hyperglycemia after meals in people with type 1 diabetes in a home setting.

• The Insulin-Only Bionic Pancreas Bridging Study
• A Randomized Clinical Trial to Assess the Efficacy of Predictive Low Glucose Suspend Versus Sensor-augmented Pump Therapy in the Management of Type 1 Diabetes (PROLOG)
• Continuous Glucose Monitoring in Pregnant Women with Type 1 Diabetes (CONCEPTT) CGM Data Management Center
• A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring on Glycemic Control in Adults with Type 1 Diabetes Using Injections for Insulin Delivery (DIAMOND)
• A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring vs Usual Care in Type 2 Diabetes Patients on Multiple Daily Insulin Injections (DIAMOND)
• A Randomized Trial to Assess the Effect of Initiating an Insulin Pump in Adults with Type 1 Diabetes Using Multiple Daily Insulin Injections and Continuous Glucose Monitoring (DIAMOND)
• A Randomized Clinical Trial to Assess the Efficacy of Adjunctive Closed Loop Control Versus Sensor-Augmented Pump Therapy in the Management of Type 1 Diabetes (iDCL protocol DCLP1)