Full public datasets are available on our Diabetes Public Datasets page.

RESEARCH HIGHLIGHTS

Upcoming presentations at the 18th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD) meeting this March;

Results from a meta-analysis collaboration with Breakthrough T1D (formerly JDRF) comparing data from five different studies and registries were published in Diabetologia in February. Continous Glucose Monitor Metrics from Five Studies Identify Participants at Risk for Type 1 Diabetes Development examined whether CGM metrics can accurately predict type 1 diabetes diagnosis.

ACTIVE STUDIES

  • INHALE-1 - A 26-week Primary Treatment Phase, with 26-week Extension, Open-label, Randomized Clinical Trial Evaluating the Efficacy and Safety of Afrezza versus Rapid-Acting Insulin Analog Injections, Both in Combination with a Basal Insulin, in Pediatric Subjects with Type 1 or Type 2 Diabetes Mellitus; NCT04974528
  • Open, Single Arm, Prospective, Multicenter Study of an Investigational Extended Wear Insulin Infusion Set during Home Use in People with Type 1 Diabetes (CB1); NCT06273124

COMPLETED STUDIES

  • A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes Continuous Glucose Monitoring Study; NCT02017171
  • A Pivotal Study of t:slim X2 with Control-IQ Technology; NCT03844789
    • A Pivotal Study of t:slim X2 with Control-IQ Technology - Extension Study
  • A Randomized Clinical Trial to Assess the Efficacy of Adjunctive Closed Loop Control Versus Sensor-Augmented Pump Therapy in the Management of Type 1 Diabetes; NCT02985866
  • A Randomized Clinical Trial to Assess the Efficacy of Predictive Low Glucose Suspend Versus Sensor-augmented Pump Therapy in the Management of Type 1 Diabetes; NCT03195140
  • A Randomized, Placebo-controlled, Double-blinded Cross-over Study of the Pharmacologic Action of a GPR119 Agonist on Glucagon Counter-regulation during Insulin-induced Hypoglycemia in Type 1 Diabetes Mellitus; NCT04432090
  • A Randomized Trial Evaluating Control-IQ Technology in Adults with Type 2 Diabetes (2IQP); NCT05785832
  • A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring on Glycemic Control in Adults with Type 1 Diabetes Using Injections for Insulin Delivery; NCT02282397
  • A Randomized Trial to Assess the Effect of Continuous Glucose Monitoring vs Usual Care in Type 2 Diabetes Patients on Multiple Daily Insulin Injections; NCT02282397
  • A Randomized Trial to Assess the Effect of Initiating an Insulin Pump in Adults with Type 1 Diabetes Using Multiple Daily Insulin Injections and Continuous Glucose Monitoring; NCT02282397
  • A Study of t:Slim X2 with Control-IQ Technology in Youth with Type 1 Diabetes; NCT03844789
  • A Validation Study of Home Blood Collection for HbA1c Measurement
  • An Observational Study of Adults with Type 3 Diabetes Using the Community-Derived Open-Source Automated Insulin Delivery Loop System (Loop T2D Observational) Study; NCT05951569
  • An Observational Study of Individuals with Type 1 Diabetes Using the Loop System for Automated Insulin Delivery
  • AIDING - Automated Insulin Delivery for Inpatients with Dysglycemia Feasibility Study; NCT04714216
  • Automated Insulin Delivery among Pregnant Women with Type 1 Diabetes (AiDAPT); NCT04938557
  • Automated Insulin Delivery in Elderly with T1D (AIDE T1D); NCT04016662
  • Closed Loop from Onset in type 1 Diabetes; NCT02871089
  • Closing the Loop in Adults with Type 1 Diabetes under Free Living Conditions with Extension to Evaluate Home Use of Closed-Loop Applying Faster Insulin Aspart Versus Standard Insulin Aspart; NCT04055480
  • Closing the Loop in Children and Adolescents with T1D in the Home Setting; NCT01778348
  • Control-IQ Technology in Individuals with Type 2 Diabetes; NCT05111301
  • Continuous Glucose Monitoring in Pregnant Women with Type 1 Diabetes CGM Data Management Center; NCT01788527
  • Continuous Glucose Monitoring in T2D Basal Insulin Users; NCT03566693
  • Day-and-Night Home Closed-Loop in Young People with Type 1 Diabetes; <ahref="https://clinicaltrials.gov/ct2/show/NCT02925299">NCT02925299
  • Direct to Patient Initiation of CGM in Diabetes
  • Evaluation of Modified Adhesives with Dexcom G6 Sensors in Individuals with Known G6 Adhesive Reactions (DEXAS); NCT04840446
  • Feasibility Assessment of Prototype Nocturnal Hypoglycemia Reduction System
  • Glycemic Variability and Fluctuations in Cognitive Status in Adults with Type 1 Diabetes (GluCog)
  • Home Testing of Day and Night Closed Loop with Pump Suspend Feature; NCT02523131
  • Hybrid Closed Loop and Verapamil for Beta Cell Preservation in New Onsets with T1D (CLVer); NCT04233034
  • In Home Closed Loop Reduction of Nocturnal Hypoglycemia and Daytime Hyperglycemia (IHCL) - datasets available on JDRF Public Website
  • INHALE-3 - Afrezza Combined with Insulin Degludec versus Usual Care in Adults with Type 1 Diabetes; NCT05904743
  • Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System; NCT01271023
  • JDRF Artifical Pancreas Project
  • JDRF Continuous Glucose Monitoring (JDRF CGM RCT) - Public Dataset
  • OP5-005 Using Omnipod 5 in Adults with Type 2 (SECURE-T2D); NCT05815342
  • Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children; NCT01823341
  • PID vs PID + Fuzzy Logic Crossover Study in Adolescents and Young Adults with Type 1 Diabetes; NCT03040414
  • Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use; NCT02137512
  • Prospective Real World Data Collection for the Bigfoot Unity Diabetes Management System: The Bigfoot Unity Real World Study (BURST); NCT05088265
  • Pump Suspension with Hyperglycemia Minimization Nocturnal Inpatient Safety and Feasibility Study
  • Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing;NCT02438189
  • Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents; NCT02714972
  • Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension: An Outpatient Pilot Feasibility and Efficacy Study; NCT01823341
  • Safety Evaluation of an Advanced Hybrid Closed Loop System Using Lyumjev with the Tandem t:slim X2 with Control-IQ in Adults, Adolescents, and Children with Type 1 Diabetes; NCT05403502
  • The Artificial Pancreas in the Very Young Children with T1D – Pilot Study; NCT03101865
  • The Artificial Pancreas in Very Young Children with T1D; NCT03784027
  • The International Diabetes Closed Loop Trial: A Randomized Crossover Comparison of Adaptive Model Predictive Control Artificial Pancreas Versus Sensor Augmented Pump/Predictive Low Glucose Suspend (PLGS) in the Outpatient Setting in Type 1 Diabetes; NCT04436769
  • The Insulin-Only Bionic Pancreas Bridging Study
  • The Insulin-Only Bionic Pancreas Pivotal Trial: Testing the iLet in Adults and Children with Type 1 Diabetes (Full protocol available here); NCT04200313
    • The Insulin-Only Bionic Pancreas Extension Study (Full protocol available here)
  • The Pediatric Artificial Pancreas trial: A Randomized Controlled Comparison of the Control-IQ technology Versus Standard of Care in Young Children in Type 1 Diabetes; NCT04796779
  • The Pediatric Artificial Pancreas Autormated Initialization Trial (PEDAP-AI); NCT06017089
  • Treat-to-Range Controller: Meal Assessment
  • Type 1 Diabetes Exercise Initiative: The Effect of Exercise on Glycemic Control in Type 1 Diabetes Pilot Study
  • Type 1 Diabetes Exercise Initiative: The Effect of Exercise on Glycemic Control in Type 1 Diabetes Study (Full protocol available here)
  • Type 1 Diabetes Exercise Initiative Pediatric Study: The Effect of Exercise on Glycemic Control in Youth with Type 1 Diabetes; Public Website (Full protocol available here
  • Virtual Diabetes Specialty Clinic: A Study Evaluating Remote Initiation of Continuous Glucose Monitoring; NCT04765358

T1D Exchange Clinic Network Studies

  • A Randomized Trial Comparing Continuous Glucose Monitoring With and Without Routine Blood Glucose Monitoring in Adults with Type 1 Diabetes; NCT02258373
  • A Study to Assess Continuous Glucose Sensor Profiles in Healthy Non-Diabetic Subjects
  • Assessment of Intranasal Glucagon in Children and Adolescents with Type 1 Diabetes; NCT01997411
  • Beta Cell Function and Glucose Counter-Regulation During the Progression of Type 1 Diabetes
  • Efficacy and Safety of Intranasal Glucagon for Treatment of Insulin Induced Hypoglycemia in Adults with Diabetes; NCT01994746
  • Hybrid Closed Loop Insulin Delivery System Data Collection
  • Improving Family Management and Glycemic Control in Youth
  • Metformin Therapy for Overweight Adolescents with T1D: A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents with Type 1 Diabetes; NCT01881828
  • Metformin Therapy for Overweight Adolescents with T1D: Insulin Clamp Ancillary Study for Assessment of Insulin Resistance; NCT02045290
  • Mini-Dose Glucagon for Adults with Type 1 Diabetes: A Study to Assess the Efficacy and Safety of Mini-Dose Glucagon for Treatment of Non-Severe Hypoglycemia in Adults with Type 1 Diabetes; NCT02411578
  • Racial Differences in Mean CGM Glucose in Relation to HbA1c
  • Residual C-Peptide in Patients with Type 1 Diabetes
  • Severe Hypoglycemia in Older Adults with Type 1 Diabetes: A Study to Identify Factors Associated with the Occurrence of Severe Hypoglycemia in Older Adults with T1D
  • Strategies to Enhance New CGM Use in Early Childhood: A Randomized Clinical Trial Assessing Continuous Glucose Monitoring Alone and Combined with a Behavioral Intervention in Youth less than 8 Years of Age with Type 1 Diabetes; NCT02912728
  • The Use of Mini-Dose Glucagon to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes; NCT02660242
  • Wireless Innovation for Seniors with Diabetes Mellitus: A Randomized Clinical Trial Assessing Continuous Glucose Monitoring in Older Adults with Type 1 Diabetes; NCT03240432

Diabetes Research in Children Network (DIRECNET) Studies

  • A Pilot Study to Assess the Accuracy of Continuous Glucose Monitors in Normal Children; NCT00069602
  • A Pilot Study to Assess the Feasibility of Real-Time Continuous Glucose Monitoring in the Management of Infants and Toddlers with Type 1 Diabetes
  • A Pilot Study to Evaluate the GlucoWatch 2 Biographer in the Management of Type 1 Diabetes in Children; NCT00069615
  • A Pilot Study to Evaluate the Navigator Continuous Glucose Sensor in the Management of Type 1 Diabetes in Children
  • A Pilot Study to Evaluate the Safety of Terbutaline in Children with Type 1 Diabetes; NCT00607503
  • A Randomized Trial to Assess the Effectiveness of the GlucoWatch Biographer in the Management of Type 1 Diabetes in Children; NCT00069628
  • A Randomized Clinical Trial to Assess the Efficacy and Safety of Real-Time Continuous Glucose Monitoring in the Management of Type 1 Diabetes in Young Children (4 to <10 Year Olds); NCT00760526
  • Cognitive and Neuroanatomical Consequences of Type 1 Diabetes in Young Children
  • Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes; NCT00891995
  • Evaluation of Counter-regulatory Hormone Responses during Hypoglycemia and the Accuracy of Continuous Glucose Monitors in Children with T1DM; NCT00607139
  • Relationship Between Loss of Beta Cell Function and Loss of the Alpha Cell Response to Hypoglycemia Early in Type 1 Diabetes
  • The Accuracy of Continuous Glucose Monitors in Children with Type 1 Diabetes; NCT00069537
  • The Effect of Basal Insulin During Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes; NCT00147342
  • The Effect of Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes